{"id":10313,"date":"2025-10-20T09:55:16","date_gmt":"2025-10-20T07:55:16","guid":{"rendered":"http:\/\/pepticore-aminos.local\/?post_type=product&p=10313"},"modified":"2026-06-04T17:23:44","modified_gmt":"2026-06-04T15:23:44","slug":"tb-500-fragment-17-23-peptide","status":"publish","type":"product","link":"https:\/\/pepticoreaminos.net\/en\/product\/tb-500-fragment-17-23-peptide\/","title":{"rendered":"TB-500 Fragment (17-23) 10mg"},"content":{"rendered":"
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TB-500 Fragment (17\u201323)<\/h1>\n

Preclinical synthesis on active structure, actin interaction, immune modulation, ad regenerative applications.<\/p>\n<\/header>\n

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What is TB-500 Fragment (17\u201323)?<\/h3>\n

TB-500 Fragment (17\u201323)<\/strong>, also known as Fequesetide<\/strong> or (17)(LKKTETQ)(23)<\/strong>, represents the smallest portion of the Thymosin Beta-4 (TB-4)<\/strong> molecule that retains the active binding domain of the larger protein. Research indicates that this synthetic derivative can bind to actin<\/strong>, an intracellular molecule responsible for cell structure, movement<\/strong>, and replication<\/strong>. By altering actin dynamics, TB-500 Fragment (17\u201323) can modulate immune response<\/strong> and reshape cell migration patterns<\/strong><\/p>\n

In animal models<\/strong>, these effects have been associated with accelerated wound healing<\/strong>, reduced inflammation<\/strong>, angiogenesis<\/strong>, less scar formation<\/strong>, improved musculoskeletal performance<\/strong>, and in some cases, slowed or reversed disease progression<\/strong>.<\/p>\n<\/article>\n

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The Role of Actin in Cellular Function<\/h3>\n

The Role of Actin in Cellular Function<\/strong>\nTo understand how TB-500 Fragment (17\u201323) works, it is essential to consider actin<\/strong> \u2014 the most abundant protein in eukaryotic cells. Actin mediates key protein-protein interactions including cell motility<\/strong>, shape maintenance<\/strong>, vesicle and organelle transport<\/strong>, cell signaling<\/strong>, junction formation<\/strong>, and cell division<\/strong>.<\/p>\n

Alongside myosin<\/strong>, it plays a fundamental role in muscle contraction<\/strong>.\nActin exists in two forms: monomeric<\/em> (G-actin) and polymerized<\/em> (F-actin or microfilaments). The transition between these forms is regulated by actin-binding proteins such as profilin<\/strong> and Thymosin Beta-4<\/strong>. Profilin promotes filament growth, while TB-4 protects actin monomers and facilitates their polymerization when required.<\/p>\n<\/article>\n

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Arp2\/3 and Branched Actin Networks<\/h3>\n

The Arp2\/3 complex<\/strong> plays a key role in cellular adaptation and actin branching. However, Arp2\/3 alone is a weak nucleator and requires assistance from other proteins such as the WASP family<\/strong>. It is hypothesized that Thymosin Beta-4<\/strong> \u2014 and thus its 17\u201323 active fragment<\/strong> \u2014 may contribute to actin network branching, essential for endocytosis<\/strong>, cellular nutrition<\/strong>, and immune phagocytosis<\/strong>.\nThe TB-500 Fragment (17\u201323) therefore serves as an excellent research tool<\/strong> to further explore these complex cellular processes.<\/p>\n<\/article>\n

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Thymosin Beta-4: The Parent Molecule<\/h3>\n

Thymosin Beta-4<\/strong> acts as a biological response modulator<\/strong> essential for the development and differentiation of T lymphocytes<\/strong>. These immune cells regulate inflammation, tissue regeneration, scar formation, infection response, and tumor control. They influence the production of inflammatory mediators such as IFN-\u03b3<\/strong>, IL-4<\/strong>, IL-5<\/strong>, and TNF-\u03b1<\/strong>.<\/p>\n<\/article>\n

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TB-4 Derivatives: TB-500 and TB-500 Fragment (17\u201323)<\/h3>\n

Thymosin Beta-4<\/strong> consists of 43 amino acids (MW \u2248 4921 g\/mol), but its active domain contains only a few residues. This discovery led to the development of TB-500<\/strong> and TB-500 Fragment (17\u201323)<\/strong> \u2014 shorter peptides retaining the same biological activity but with greater bioavailability<\/strong>.<\/p>\n

Both share the same heptapeptide sequence (LKKTETQ)<\/strong> but differ in molecular weight<\/strong> and chemical formula<\/strong>. TB-500: 889.0 g\/mol (C38H68N10O14); TB-500 Fragment (17\u201323): 846.97 g\/mol (C36H66N10O13).\nThe absence of an aldehyde group<\/strong> in the fragment makes it more stable<\/strong> and more resistant to degradation<\/strong>, leading to a longer half-life. It is highly soluble in water (>60 mg\/mL).<\/p>\n<\/article>\n

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Healing and Tissue Repair<\/h3>\n

TB-500 Fragment (17\u201323) plays a dual role in repair through fibroblast migration<\/strong> and angiogenesis<\/strong>. Fibroblasts are key in rebuilding the extracellular matrix (ECM)<\/strong> and closing wounds; by modulating actin, the fragment enhances their migration to injured tissue.<\/p>\n

It also activates TGF-\u03b2<\/strong>, which promotes fibroblast activity<\/strong> and collagen production<\/strong> \u2014 both crucial for ECM reconstruction.<\/p>\n

Moreover, TB-500 Fragment (17\u201323) promotes endothelial cell migration<\/strong> and increases the release of VEGF<\/strong> and other angiogenic factors<\/strong>, improving oxygenation<\/strong> and nutrient delivery<\/strong> to damaged areas.\nIn wound and corneal injury models, it has demonstrated faster healing<\/strong>, reduced apoptosis<\/strong>, and lower cytokine activity<\/strong>.<\/p>\n<\/article>\n

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Muscle Tissue and Musculoskeletal Recovery<\/h3>\n

Muscle fibers are composed of actin<\/strong> and myosin<\/strong>. TB-500 Fragment (17\u201323) activates satellite cells<\/strong> \u2014 the stem cells responsible for muscle regeneration<\/strong> \u2014 through the Akt signaling pathway<\/strong>, promoting cell cycle progression and fiber repair<\/strong>.<\/p>\n

t belongs to the class of cell-penetrating peptides<\/strong>, meaning it can cross cell membranes<\/strong> and even the nuclear envelope<\/strong> without transporters. Its smaller size and improved bioavailability<\/strong> allow it to reach dense tissues more efficiently, resulting in superior functional recovery<\/strong> compared to native Thymosin Beta-4.\nIn animal studies, TB-500 administration improved muscle strength<\/strong>, endurance<\/strong>, and motor coordination<\/strong>.<\/p>\n<\/article>\n

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Inflammation and Immune Modulation<\/h3>\n

Inflammation is essential for healing but must be properly controlled. TB-500 Fragment (17\u201323) acts as a balancing modulator<\/strong>, enhancing inflammation when needed and reducing it once repair begins<\/strong>.\nIt has been shown to lower TNF-\u03b1<\/strong> and IL-6<\/strong> levels locally at the injury site, avoiding the systemic immunosuppression typical of global anti-inflammatory drugs.<\/p>\n

It also promotes the release of anti-inflammatory cytokines<\/strong> and the recruitment of immune cells<\/strong> to resolve inflammation, suggesting potential in rheumatoid arthritis<\/strong>, inflammatory bowel disease<\/strong>, and lupus<\/strong> research.<\/p>\n<\/article>\n

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Cell Signaling: Akt and Bcl-XL<\/h3>\n

TB-500 Fragment (17\u201323) influences cell survival through Akt<\/strong> and Bcl-XL<\/strong> pathways. Akt<\/strong> prevents excessive apoptosis and accelerates the G1\u2192S cell cycle transition<\/strong>, enhancing fibroblast<\/strong> and endothelial cell proliferation<\/strong> during wound repair and regeneration.<\/p>\n<\/article>\n

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Neurological Restoration<\/h3>\n

Nervous system repair involves not only neurons but also glial and support cells. Thymosin Beta-4<\/strong> has been shown to promote axon growth<\/strong>, neurite extension<\/strong>, and neuron survival<\/strong>.\nGiven that these effects originate from the same 17\u201323 active domain<\/strong>, TB-500 Fragment (17\u201323)<\/strong> is believed to share similar neuroprotective properties.<\/p>\n

Studies have shown increased oligodendrocyte markers<\/strong> \u2014 cells involved in neurogenesis<\/strong> \u2014 in a dose-dependent manner<\/strong>.\nIt also upregulates miR-146a<\/strong>, a microRNA linked to anti-inflammatory effects<\/strong> crucial for neuron regeneration.\nThis makes TB-500 Fragment (17\u201323) a peptide of interest in conditions such as multiple sclerosis<\/strong>, where remyelination<\/strong> and neuroprotection<\/strong> are key goals.<\/p>\n<\/article>\n

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Summary<\/h3>\n

TB-500<\/strong> and TB-500 Fragment (17\u201323)<\/strong> share many biological properties of Thymosin Beta-4, including anti-inflammatory activity<\/strong>, cell proliferation<\/strong>, and tissue regeneration<\/strong> in the skin, muscle, heart, and brain.\nIts structural differences make TB-500 Fragment (17\u201323)<\/strong> the smallest, most stable, and most bioavailable<\/strong> of the group, with a longer half-life and greater resistance to degradation.<\/p>\n

All available data come from preclinical and early clinical research<\/strong>; this compound is intended strictly for scientific research use<\/strong>.<\/p>\n<\/article>\n

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Scientific References<\/h3>\n
    \n
  1. PubMed: 22962027 \u2014 Peptide TB-500 Fragment (17\u201323) e funzione cellulare<\/a><\/li>\n
  2. PubChem CID: 10169788 \u2014 TB-500 Fragment (17\u201323) (Fequesetide)<\/a><\/li>\n<\/ol>\n<\/article>\n<\/section>","protected":false},"excerpt":{"rendered":"

    TB-500 Fragment (17\u201323)<\/strong>, also known as Fequesetide<\/strong> or acetyl-TB500<\/strong>, is a synthetic peptide<\/strong> corresponding to amino acids 17\u201323 of the Thymosin Beta-4<\/strong> sequence \u2014 the smallest active fragment retaining the biological properties of the parent molecule.\nThe addition of an acetyl group<\/strong> enhances its molecular stability<\/strong>, extends its duration of action up to 36 hours<\/strong>, and results in a molecular weight of approximately 889 Da<\/strong>.<\/p>\n

    In preclinical studies, TB-500 Fragment (17\u201323)<\/strong> has been shown to modulate immune response<\/strong> and regulate cell migration<\/strong>, supporting faster wound healing<\/strong>, reduced inflammation<\/strong>, and enhanced angiogenesis<\/strong>.\nEvidence also suggests it is more effective than full-length TB-500<\/strong> in promoting tissue regeneration<\/strong>, minimizing scar formation<\/strong>, and improving musculoskeletal recovery<\/strong>, making it one of the most promising research compounds in healing and regenerative studies<\/strong>.<\/p>","protected":false},"featured_media":11355,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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