{"id":10311,"date":"2025-10-19T23:35:09","date_gmt":"2025-10-19T21:35:09","guid":{"rendered":"http:\/\/pepticore-aminos.local\/?post_type=product&p=10311"},"modified":"2026-06-04T17:12:38","modified_gmt":"2026-06-04T15:12:38","slug":"ara-290-peptide","status":"publish","type":"product","link":"https:\/\/pepticoreaminos.net\/en\/product\/ara-290-peptide\/","title":{"rendered":"ARA-290 (Cibinetide) 16mg"},"content":{"rendered":"
\n
\n

ARA-290 (Cibinetide)<\/h1>\n

Peptide sperimentale per la ricerca su neuropatia, infiammazione, rigenerazione tissutale e protezione vascolare.<\/p>\n<\/header>\n

\n

What is ARA-290<\/h3>\n

ARA-290<\/strong>, also known as Cibinetide<\/strong>, is a peptide derived from the beta-helix domain of erythropoietin (EPO)<\/strong>.\nUnlike EPO, which stimulates red blood cell production, ARA-290 retains its neuroprotective and anti-inflammatory properties<\/strong> without affecting erythropoiesis.\nResearch has shown that the peptide acts through Innate Repair Receptors (IRR)<\/strong> and Tissue-Protective Receptors (TPR)<\/strong>, modulating immune response and promoting cellular regeneration.<\/p>\n

In preclinical and phase II clinical studies, ARA-290 demonstrated a reduction in neuropathic pain<\/strong>, a decrease in systemic inflammatory markers<\/strong>, and enhanced cell survival<\/strong>.\nIt is currently undergoing phase III trials<\/strong> for neuropathies related to diabetes and autoimmune sarcoidosis.<\/p>\n<\/article>\n

\n

Vascular Health and Angiogenesis<\/h3>\n

In experimental models of retinal ischemia<\/strong>\u2014one of the leading causes of blindness\u2014ARA-290<\/strong> has shown the ability to protect endothelial cells<\/strong> from inflammatory damage and promote their regeneration.\nStudies indicate that the peptide prolongs the survival of endothelial progenitor cells (ECFCs)<\/strong>, stimulates their proliferation and migration<\/strong>, and enhances their homing ability<\/strong> toward damaged tissues.<\/p>\n

These properties open new perspectives for vascular repair<\/strong> and ischemic tissue regeneration<\/strong>, improving blood flow and oxygenation in compromised tissues.\nThe ability of ARA-290 to support endothelial function also suggests a potential role in post-infarction recovery<\/strong> and diabetic microvascular disorders<\/strong>.<\/p>\n<\/article>\n

\n

Modulation of Inflammatory Cytokines<\/h3>\n

Research in animal models shows that ARA-290<\/strong> significantly reduces the production of pro-inflammatory cytokines<\/strong> such as IL-6<\/strong>, IL-12<\/strong>, and TNF-\u03b1<\/strong>.\nThis effect is mediated through binding to the Tissue-Protective Receptor (TPR)<\/strong>, triggering a cascade of signals that limit apoptosis<\/strong> and promote regeneration<\/strong>.<\/p>\n

In particular, ARA-290 can prolong the survival of transplanted pancreatic cells<\/strong> in diabetic models by counteracting macrophage activation responsible for rejection.\nThese findings represent a potential breakthrough in islet cell replacement therapy<\/strong> and anti-rejection strategies<\/strong> after transplantation.<\/p>\n<\/article>\n

\n

Effects on the Immune System<\/h3>\n

The TPR<\/strong> is expressed on various immune cells, including macrophages, dendritic cells, mast cells, and T-lymphocytes<\/strong>.\nARA-290 acts on these receptors to reduce the secretion of pro-inflammatory cytokines<\/strong> (TNF-\u03b1, IL-6) and limit inflammatory chemotaxis.\nAt the same time, it promotes the recruitment of resident macrophages<\/strong> in injured tissues, supporting balanced and accelerated healing<\/strong>.<\/p>\n

Other studies show that the peptide can modulate dendritic cell antigen presentation<\/strong>, influencing adaptive immune response and reducing organ rejection<\/strong> in experimental transplants.\nThese functions make ARA-290 a promising candidate in the study of new selective immunomodulatory therapies<\/strong>, applicable to conditions such as autoimmune colitis, Crohn\u2019s disease, and systemic lupus erythematosus (SLE)<\/strong>.<\/p>\n<\/article>\n

\n

Neuropathic Pain and Neuroprotection<\/h3>\n

One of the most promising areas of ARA-290<\/strong> research concerns peripheral neuropathy<\/strong>.\nThe peptide acts on IRR (Innate Repair Receptors)<\/strong> and modulates TRPV1 channel activity<\/strong>, which is responsible for heat perception and the burning pain typical of diabetic or autoimmune neuropathies.\nThis dual mechanism contributes to reducing neuroinflammation<\/strong> and restoring small nerve fiber function<\/strong>.<\/p>\n

Clinical studies in patients with sarcoid or diabetic neuropathy<\/strong> have shown an increase in intraepidermal nerve fiber density<\/strong> and a significant reduction in pain<\/strong>.\nThese results suggest that ARA-290 may represent a new therapeutic approach for refractory neuropathies, including conditions such as HIV, multiple sclerosis, or celiac disease<\/strong>.<\/p>\n<\/article>\n

\n

Orphan Drug Status and Clinical Trials<\/h3>\n

In 2016<\/strong>, the FDA<\/strong> granted ARA-290 (Cibinetide)<\/strong> orphan drug status<\/strong> for the treatment of painful sarcoid neuropathy<\/strong>.\nThe following year, scientific publications led by Michael Brines<\/strong> confirmed the peptide\u2019s efficacy in treating peripheral neuropathic pain<\/strong> and promoting small nerve fiber regeneration<\/strong>.<\/p>\n

Currently, ARA-290<\/strong> is in phase III clinical trials<\/strong> for diabetic and sarcoid neuropathy, but its potential also extends to autoimmune diseases, ischemic injuries, and slow wound healing<\/strong>.<\/p>\n<\/article>\n

\n

Research and Safety<\/h3>\n

ARA-290<\/strong> has shown a favorable safety profile<\/strong> with minimal side effects<\/strong> and high subcutaneous bioavailability<\/strong> in preclinical studies.\nThanks to its targeted anti-inflammatory mechanism<\/strong> and receptor selectivity<\/strong>, it is considered a valuable candidate for research in neuroprotective, vascular, and immunoregulatory therapies<\/strong>.<\/p>\n

All Pepticore Aminos<\/strong> products are intended strictly for scientific research use<\/strong> (Research Use Only<\/em>) and are not to be used for diagnostic or therapeutic purposes.<\/p>\n<\/article>\n

\n

Scientific References<\/h3>\n
    \n
  1. PubMed: 25387363 \u2014 Neuroprotective and anti-inflammatory effects of ARA-290<\/a><\/li>\n
  2. PubMed: 24555851 \u2014 Cibinetide and tissue repair mechanisms<\/a><\/li>\n
  3. PubMed: 24529189 \u2014 ARA-290 in diabetic neuropathy models<\/a><\/li>\n
  4. PubMed: 26774587 \u2014 Clinical study on small fiber neuropathy and sarcoidosis<\/a><\/li>\n<\/ol>\n<\/article>\n<\/section>","protected":false},"excerpt":{"rendered":"

    ARA-290<\/strong> is a peptide derived from erythropoietin<\/strong>, studied for its anti-inflammatory<\/strong>, neuroprotective<\/strong>, and tissue-repairing<\/strong> properties. Acting on innate repair receptors<\/strong> through paracrine signaling<\/strong>, ARA-290<\/strong> has shown the ability to reduce neuropathic pain<\/strong>, enhance wound healing<\/strong>, and modulate immune response<\/strong>.<\/p>","protected":false},"featured_media":11390,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[50],"product_cat":[55,70,67],"product_tag":[],"class_list":["post-10311","product","type-product","status-publish","has-post-thumbnail","product_brand-pepticore-aminos","product_cat-guarigione-recupero","product_cat-peptidi-liofilizzati-fiale","product_cat-supporto-immunitario","desktop-align-center","tablet-align-center","mobile-align-center","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/product\/10311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/comments?post=10311"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/media\/11390"}],"wp:attachment":[{"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/media?parent=10311"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/product_brand?post=10311"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/product_cat?post=10311"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pepticoreaminos.net\/en\/wp-json\/wp\/v2\/product_tag?post=10311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}