Melanotan 1 (MT-1) 10mg

48,90 €

Melanotan 1 (MT-1), also known as Afamelanotide, is a synthetic analogue of α-MSH, studied primarily for its role in the regulation of skin pigmentation and melanogenesis.
Its activity is mainly associated with the MC-1R receptor, expressed on melanocytes, where it contributes to the production of eumelanin, the dark pigment involved in the skin’s biological response to UV light. Compared to Melanotan 2, MT-1 has a more targeted profile on pigmentation and a less broad neuroendocrine activity.
Melanotan-I is supplied in lyophilized form and is intended exclusively for research and laboratory applications.

Availability: In stock

Independent laboratory analysis available

Report linked to the currently available batch.

Latest tested batchPC-M110-0529W

Purity99.764%

Quantity9.96mg

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Melanotan 1 (MT-1)

Melanotan 1 (MT-1), also known as Afamelanotide or NDP-α-MSH, is a synthetic peptide derived from the natural melanocortin hormone α-MSH. It belongs to the melanocortin peptide family, molecules involved in the regulation of skin pigmentation, melanocyte response, and biological processes associated with melanin production.

MT-1 was developed as a more stable analogue of α-MSH, with structural modifications designed to increase resistance to enzymatic degradation and prolong biological activity compared to the natural peptide. For this reason, it has been widely studied in research models dedicated to melanogenesis, cutaneous photobiology, and regulation of the melanocortin receptor MC-1R.

Unlike Melanotan 2 (MT-2), which has a broader receptor profile and is also analyzed for interactions with neuroendocrine pathways, appetite, behavior, and central receptors such as MC-3R and MC-4R, Melanotan 1 is generally considered more focused on pigmentation and melanocyte activity. This distinction makes MT-1 a molecule of interest when the research objective primarily concerns eumelanin production and the skin’s biological response to light stimuli.

Mechanism of Action and Melanogenesis

The activity of Melanotan 1 is primarily linked to the stimulation of the MC-1R receptor, expressed on melanocytes. Activation of this receptor promotes a cascade of intracellular signals that increases the production of eumelanin, the dark pigment associated with skin coloration and the skin’s natural response to ultraviolet light.

In cellular models, activation of the MC-1R pathway promotes an increase in cAMP and the activity of factors involved in melanin synthesis, including enzymes such as tyrosinase. This process contributes to the regulation of melanogenesis and allows the study of how melanocortin signals influence the quantity and quality of the pigment produced by melanocytes.

Eumelanin production is relevant because this pigment has a greater ability to absorb and dissipate part of the energy derived from UV radiation compared to pheomelanin. For this reason, MT-1 has been used as a reference in the study of the biological mechanisms linking α-MSH, MC-1R, pigmentation, and cutaneous photoprotection.

Differences Between Melanotan 1 and Melanotan 2

Although both are derived from α-MSH, Melanotan 1 and Melanotan 2 are not equivalent. Melanotan 1 is a linear analogue of α-MSH and is more closely associated with stimulation of the MC-1R receptor and melanin production. Its main field of research concerns pigmentation, melanocyte response, and cutaneous biology.

Melanotan 2, on the other hand, is a cyclic molecule with broader activity across different melanocortin receptors. In addition to MC-1R, it can interact with receptors such as MC-3R and MC-4R, which are also present in areas of the central nervous system involved in the regulation of appetite, energy balance, and other neuroendocrine signals.

In research terms, MT-1 is therefore considered more targeted for the study of melanogenesis and pigmentation, while MT-2 is used in broader models, where the interest is not limited to melanocytes but also includes the interaction between the peripheral and central melanocortin system. This difference is important for correctly distinguishing the two molecules and their different roles in experimental protocols.

Relevance in Pigmentation Research

Melanotan 1 has contributed significantly to the study of the biological axis α-MSH → MC-1R → melanogenesis. Its ability to stimulate eumelanin production makes it a useful molecule for analyzing melanocyte behavior, pigmentation regulation, and the cellular mechanisms associated with the response to UV light.

The literature on Afamelanotide has also made MT-1 an important reference in research on cutaneous photobiology. The main interest is not only related to increased pigmentation, but also to the understanding of the molecular signals that allow melanocytes to adapt to environmental stimuli and modulate melanin production.

This makes Melanotan 1 particularly suitable for laboratory contexts focused on the study of pigmentation, melanocyte function, MC-1R signaling, and biological processes linked to α-MSH.

Melanotan 1 PepticoreAminos

Melanotan 1 Pepticore is supplied in lyophilized form and is intended exclusively for research and laboratory applications. The product is designed for experimental studies on melanogenesis, pigmentation, MC-1R receptor activity, and biological pathways linked to α-MSH.

Each batch is accompanied by analytical documentation to support research activities that require traceability, quality control, and confirmation of molecular identity. The lyophilized form promotes better stability of the compound before reconstitution, making it suitable for contexts where controlled storage and experimental reproducibility are required.

Melanotan 1 should not be confused with Melanotan 2: MT-1 has a profile more oriented toward pigmentation and MC-1R signaling, while MT-2 shows broader activity across different melanocortin receptors. This distinction allows the compound to be selected more consistently according to the research objective.

mg	10mg

Peptide Technical Data

Product Name	Melanotan 1 (MT-1) / Afamelanotide
CAS Number	75921-69-6
PubChem CID	16164658
Peptide Sequence	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
Molecular Formula	C₇₈H₁₁₁N₂₁O₁₉
Molecular Weight	1646.8 g/mol
Purity	≥99% (HPLC validated)
Synthesis Method	Solid-Phase Peptide Synthesis (SPPS)
Format	Lyophilized powder
Appearance	White to off-white powder
Solubility	Soluble in water, PBS, minimal acidic buffers
Stability & Storage	−20°C for long-term storage; post-reconstitution: 4°C short term, −20°C for extended storage
Regulatory Status	Research use only; not for human consumption

Disclaimer - Research Use Only

The products offered by Pepticore Aminos are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including – but not limited to – diagnostic, therapeutic, or recreational purposes.

By making a purchase, the customer declares that:

they are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;
they will use the product in full compliance with all applicable local, national, and European Union laws and regulations;
they will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited uses:

The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;
Any direct administration or use on humans or animals is strictly prohibited;
Pepticore Aminos does not endorse or permit the use of its products for the production, testing, or development of illegal substances.

Regulatory compliance:

Pepticore Aminos does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.

Liability:

L’acquirente si assume ogni responsabilità per la manipolazione, conservazione e utilizzo del prodotto in condizioni sicure e conformi alla legge.
Pepticore Aminos non potrà essere ritenuta responsabile per danni diretti o indiretti derivanti da un uso improprio, dallo stoccaggio non corretto o da un utilizzo non autorizzato del prodotto.
Pepticore Aminos si riserva il diritto di rifiutare la vendita a qualsiasi individuo o ente sospettato di uso improprio dei propri prodotti.

In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.

Storage

Storage Instructions

All Pepticore Aminos products are manufactured using a lyophilization (freeze-drying) process, which ensures product stability during shipping for up to 3–4 months.

Once reconstituted (mixed with bacteriostatic water), the peptides should be stored in the refrigerator to maintain stability. After reconstitution, they remain stable for up to 30 days.

What is Lyophilization

Lyophilization is a dehydration process, also known as cryodesiccation, in which peptides are first frozen and then exposed to low pressure. Under these conditions, the water in the vial sublimates directly from solid to gas, leaving behind a stable, white crystalline structure (lyophilized peptide).

The white powder can be stored at room temperature until reconstitution with bacteriostatic water.

Storage After Delivery

Keep peptides cool and protected from light. For use within a few days, weeks, or months, simple refrigeration at a temperature of < 4 °C (39 °F) is sufficient.

Lyophilized peptides are generally stable at room temperature for several weeks or longer; if use is expected within a few weeks or months, this storage condition is acceptable.

Long-Term Storage

For periods of several months or years, storage in a −80 °C (−112 °F) freezer is recommended as the optimal solution to preserve peptide stability.

For more information on proper storage techniques, visit:
Peptide Storage Information

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