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⚠️ For research and laboratory use only. Not for human or animal use.

SNAP-8

⚠️ For research and laboratory use only. Not for human or animal use.

SNAP-8

45,00 €

SNAP-8 is a SNAP-25 mimetic peptide that modulates the formation of the SNARE complex, reducing the muscle contractions responsible for expression wrinkles.
It acts as a safe and gentle topical alternative to botulinum toxin, helping to reduce the depth of wrinkles on the forehead and around the eyes.
Used in cosmetic formulations such as serums, emulsions, and gels for a visible smoothing and relaxing effect.
Longevity
Solvent not included. Add Bacteriostatic Water.
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Laboratory analysis available (COA)Latest tested batch: PC-SNAP10-1311U — 10mg

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SNAP-8

SNAP-8 (Acetyl Glutamyl Heptapeptide-1) is a next-generation biomimetic peptide designed to reduce the depth of expression wrinkles, particularly in the forehead and eye contour areas. It is derived from the N-terminal fragment of the SNAP-25 protein, an essential component of the SNARE complex involved in neurotransmitter release. Acting as a competitive antagonist of SNAP-25, SNAP-8 modulates the formation of the SNARE complex, reducing the ability of synaptic vesicles to fuse with the neuronal membrane. This results in a decrease in acetylcholine release and, consequently, an attenuation of the muscle contraction responsible for the formation of fine lines and expression wrinkles.

Mechanism of Action

SNAP-8 acts specifically on the process of cholinergic neurotransmission. Its structure is analogous to the N-terminal end of the SNAP-25 peptide, a protein involved in the fusion of neurotransmitter-containing vesicles with the presynaptic membrane. When SNAP-8 is introduced, it partially binds to the SNARE complex, preventing it from fully assembling. The result is a slight destabilization of the complex, which reduces the efficiency of neurotransmitter release.
The lower availability of acetylcholine at the neuromuscular junctions leads to a less intense contraction of facial expression muscles. Over time, this results in a visible reduction in the depth of wrinkles and expression lines, without compromising the natural expressiveness of the face.
This mechanism is conceptually similar to that of botulinum toxin, but with a topical and non-invasive approach: SNAP-8 does not paralyze the muscle fiber but instead softens its reactivity, making it safer, gentler, and reversible.

Cosmetic Benefits

The use of SNAP-8 in cosmetics has become widespread as a topical alternative to Botox®, thanks to its proven effectiveness in improving skin appearance and reducing dynamic wrinkles. Its main benefits include:

  • Significant reduction in the depth of expression wrinkles in the forehead and periocular area (crow’s feet);
  • Immediate and progressive smoothing effect with continued use;
  • A safer, more affordable, and non-invasive alternative to botulinum toxin injections;
  • Compatibility with a wide range of cosmetic formulations (serums, creams, emulsions, gels, masks);
  • Suitable for targeted anti-aging treatments and soothing formulas for sensitive or mature skin.

The overall effect is an improvement in skin appearance, with smoother, more relaxed, and visibly rejuvenated skin, without any loss of natural facial expressiveness.

Physicochemical Properties and Formulation

SNAP-8 is generally supplied as a lyophilized powder or as a ready-to-use aqueous solution (0.5 g/L). The powder has a white-ivory appearance and may exhibit crystalline polymorphic behavior, with possible variations in particle size or aggregation. This phenomenon is not related to chemical changes but represents a normal characteristic of lyophilized peptide products.
The peptide is highly soluble in water, PBS, and weak acidic buffers, and can be incorporated during the final stage of cosmetic formulation, provided the temperature does not exceed 40 °C to maintain compound stability.
For optimal efficacy, it is recommended to include SNAP-8 Solution at concentrations between 3% and 10% in the final formula. The use of advanced delivery systems (liposomes, nanosomes, peptosomes) can enhance skin penetration and maximize topical bioavailability.

Safety Profile and Tolerability

One of the main advantages of SNAP-8 is its high level of safety. Since it acts only locally and topically, it does not interfere with systemic neurotransmission or alter the physiological functions of the skin. Laboratory studies and clinical tests conducted on formulations containing SNAP-8 have demonstrated excellent skin compatibility, with no significant irritation or sensitization.
The peptide’s effect is reversible and depends on the duration of application: discontinuing the treatment leads to a gradual return to normal muscle contractility, without any permanent effects.

Applications and Conclusions

SNAP-8 represents one of the most promising innovations in the field of peptide-based cosmetology, combining efficacy and safety. It is suitable for anti-aging formulations designed for:

  • Dynamic expression wrinkles (forehead, glabellar area, eye contour);
  • Mature or stressed skin affected by intense facial expressions;
  • Daily maintenance treatments following aesthetic procedures;
  • Concentrated serums or booster products with an immediate smoothing effect.

In summary, SNAP-8 offers a modern, scientifically grounded approach to reducing expression lines, acting as a “topical neuromodulating peptide” that smooths the skin and visibly improves its quality over time. The product and its use are intended for research purposes only.

mg

10mg

Peptide Technical Data

Product Name SNAP-8
CAS Number 2023788-19-2
Sequence (Truncated) Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Molecular Formula C₄₁H₇₀N₁₆O₁₆S
Molecular Weight 1075.16 g/mol
Purity ≥99% (HPLC validated)
Synthesis Method Recombinant peptide or SPPS variant, depending on supplier
Format Lyophilized powder
Appearance White to off-white powder
Solubility Soluble in water, PBS, or minimal acid buffers
Stability & Storage −20°C up to 18 months; post-reconstitution: 4°C ≤10 days; −20°C ≤6 months
Regulatory Status Research use only; not for human consumption

Storage

Storage Instructions

All Pepticore Aminos products are manufactured using a lyophilization (freeze-drying) process, which ensures product stability during shipping for up to 3–4 months.

Once reconstituted (mixed with bacteriostatic water), the peptides should be stored in the refrigerator to maintain stability. After reconstitution, they remain stable for up to 30 days.

What is Lyophilization

Lyophilization is a dehydration process, also known as cryodesiccation, in which peptides are first frozen and then exposed to low pressure. Under these conditions, the water in the vial sublimates directly from solid to gas, leaving behind a stable, white crystalline structure (lyophilized peptide).

The white powder can be stored at room temperature until reconstitution with bacteriostatic water.

Storage After Delivery

Keep peptides cool and protected from light. For use within a few days, weeks, or months, simple refrigeration at a temperature of < 4 °C (39 °F) is sufficient.

Lyophilized peptides are generally stable at room temperature for several weeks or longer; if use is expected within a few weeks or months, this storage condition is acceptable.

Long-Term Storage

For periods of several months or years, storage in a −80 °C (−112 °F) freezer is recommended as the optimal solution to preserve peptide stability.

For more information on proper storage techniques, visit:
Peptide Storage Information

Disclaimer - Research Use Only

The products offered by Pepticore Aminos are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including – but not limited to – diagnostic, therapeutic, or recreational purposes.

By making a purchase, the customer declares that:

  • they are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;
  • they will use the product in full compliance with all applicable local, national, and European Union laws and regulations;
  • they will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited uses:

  • The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;
  • Any direct administration or use on humans or animals is strictly prohibited;
  • Pepticore Aminos does not endorse or permit the use of its products for the production, testing, or development of illegal substances.

Regulatory compliance:

Pepticore Aminos does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.

Liability:

L’acquirente si assume ogni responsabilità per la manipolazione, conservazione e utilizzo del prodotto in condizioni sicure e conformi alla legge.
Pepticore Aminos non potrà essere ritenuta responsabile per danni diretti o indiretti derivanti da un uso improprio, dallo stoccaggio non corretto o da un utilizzo non autorizzato del prodotto.
Pepticore Aminos si riserva il diritto di rifiutare la vendita a qualsiasi individuo o ente sospettato di uso improprio dei propri prodotti.

In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.

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